Lawrence Livermore National Laboratory



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The Department of Defense's Defense Advanced Research Projects Agency (DARPA) selected Lawrence Livermore National Laboratory (LLNL) to develop an implantable neural device with the ability to record and stimulate neurons within the brain to help restore memory.

The research builds on the understanding that memory is a process in which neurons in certain regions of the brain encode information, store it and retrieve it. Certain types of illnesses and injuries, including Traumatic Brain Injury (TBI), Alzheimer's disease and epilepsy, disrupt this process and cause memory loss. TBI, in particular, has affected 270,000 military service members since 2000.

The goal of LLNL's work -- driven by LLNL's Neural Technology group and undertaken in collaboration with the University of California, Los Angeles (UCLA) and Medtronic -- is to develop a device that uses real-time recording and closed-loop stimulation of neural tissues to bridge gaps in the injured brain and restore individuals' ability to form new memories and access previously formed ones.

The research is funded by DARPA's Restoring Active Memory (RAM) program.

Specifically, the Neural Technology group will seek to develop a neuromodulation system -- a sophisticated electronics system to modulate neurons -- that will investigate areas of the brain associated with memory to understand how new memories are formed. The device will be developed at LLNL's Center for Bioengineering.

LLNL will develop a miniature, wireless and chronically implantable neural device that will incorporate both single neuron and local field potential recordings into a closed-loop system to implant into TBI patients' brains. The device -- implanted into the entorhinal cortex and hippocampus -- will allow for stimulation and recording from 64 channels located on a pair of high-density electrode arrays. The entorhinal cortex and hippocampus are regions of the brain associated with memory.

The arrays will connect to an implantable electronics package capable of wireless data and power telemetry. An external electronic system worn around the ear will store digital information associated with memory storage and retrieval and provide power telemetry to the implantable package using a custom RF-coil system.

Designed to last throughout the duration of treatment, the device's electrodes will be integrated with electronics using advanced LLNL integration and 3D packaging technologies. The microelectrodes that are the heart of this device are embedded in a biocompatible, flexible polymer.

Lawrence Livermore's collaborators, UCLA and Medtronic, will focus on conducting clinical trials and fabricating parts and components, respectively.

LLNL's work on the Restoring Active Memory program supports President Obama's Brain Research through Advancing Innovative Neurotechnologies (BRAIN) initiative.